PME100879
Human IL10R Protein; hFc Tag
Size
£202.00
- SKU:
- PME100879
- Additional Names:
- CD210;CD210a;CDW210A;HIL-10R;IL-10R1;IL10RA
- Molecular Weight:
- The protein has a predicted molecular mass of 50.5 kDa after removal of the signal peptide. The apparent molecular mass of IL10R-hFc is approximately 70-100 kDa due to glycosylation.
- Purity:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- IL10R
- IL10R(His22-Asn235) hFc(Glu99-Ala330):
- IL10R(His22-Asn235) hFc(Glu99-Ala330)
- Extra Details:
- The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10; and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants; one protein-coding and the other not protein-coding; have been found for this gene. [provided by RefSeq; Jan 2009]
- Shipping Conditions:
- Ambient