PME100783
Human AGR2 Protein; hFc Tag
Size
£202.00
- SKU:
- PME100783
- Additional Names:
- AG-2;hAG-2;HPC8
- Molecular Weight:
- The protein has a predicted molecular mass of 44.0 kDa after removal of the signal peptide. The apparent molecular mass of AGR2-hFc is approximately 35-55 kDa due to glycosylation.
- Purity:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- AGR2
- AGR2(Arg21-Leu175) hFc(Glu99-Ala330):
- AGR2(Arg21-Leu175) hFc(Glu99-Ala330)
- Extra Details:
- This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence; a catalytically active thioredoxin domain; and a C-terminal ER-retention sequence. This protein plays a role in cell migration; cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone; it plays a role in the folding; trafficking; and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq; Mar 2017]
- Shipping Conditions:
- Ambient