PME100762
Human RNF43 Protein; mFc Tag
Size
£202.00
- SKU:
- PME100762
- Additional Names:
- RNF124;SSPCS;URCC
- Molecular Weight:
- The protein has a predicted molecular mass of 39.4 kDa after removal of the signal peptide. The apparent molecular mass of RNF43-mFc is approximately 40-70 kDa due to glycosylation.
- Purity:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- RNF43
- RNF43(Glu43-Tyr197) mFc(Pro99-Lys330):
- RNF43(Glu43-Tyr197) mFc(Pro99-Lys330)
- Extra Details:
- The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain; a protease-associated domain; an ectodomain; and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling; and expression of this gene results in an increase in ubiquitination of frizzled receptors; an alteration in their subcellular distribution; resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells; including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq; Mar 2015]
- Shipping Conditions:
- Ambient