Human TSLP Protein; hFc Tag

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£219.00

SKU:: PME100637
Additional Names:: TSLP
Molecular Weight:: The protein has a predicted molecular mass of 41.1 kDa after removal of the signal peptide. The apparent molecular mass of TSLP-hFc is approximately 55-70 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: TSLP
TSLP(Tyr29-Gln159) hFc(Glu99-Ala330):: TSLP(Tyr29-Gln159) hFc(Glu99-Ala330)
Extra Details:: This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c( ) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases; including asthma; allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition; the shorter (predominant) isoform is an antimicrobial protein; displaying antibacterial and antifungal activity against B. cereus; E. coli; E. faecalis; S. mitis; S. epidermidis; and C. albicans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq; Jul 2020]

Shipping Conditions:: Ambient