Human GFRAL Protein; His Tag

Size

£181.00

SKU:: PME100621
Additional Names:: bA360D14.1;C6orf144;GRAL;UNQ9356
Molecular Weight:: The protein has a predicted molecular mass of 38.6 kDa after removal of the signal peptide. The apparent molecular mass of GFRAL-His is approximately 35-55 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: GFRAL
GFRAL(Ser19-Glu351) 6×His tag:: GFRAL(Ser19-Glu351) 6×His tag
Extra Details:: Brainstem-restricted receptor for GDF15 which regulates food intake; energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886; PubMed:28846097; PubMed:28846098; PubMed:28846099). Upon interaction with its ligand; GDF15; interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.[UniProtKB/Swiss-Prot Function]