PME100546
Human PSMA Protein; mFc Tag
Size
£181.00
- SKU:
- PME100546
- Additional Names:
- FGCP;FOLH;GCP2;GCPII;mGCP;NAALAD1;NAALAdase;PSM;PSMA
- Molecular Weight:
- The protein has a predicted molecular mass of 105.8 kDa after removal of the signal peptide.The apparent molecular mass of mFc-PSMA is approximately 130 kDa due to glycosylation.
- Purity:
- The purity of the protein is greater than 90% as determined by SDS-PAGE and Coomassie blue staining.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- PSMA
- mFc(Pro99-Lys330) PSMA(Lys44-Ala750):
- mFc(Pro99-Lys330) PSMA(Lys44-Ala750)
- Extra Details:
- This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates; including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate; central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates; resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
- Shipping Conditions:
- Ambient