Human TMEM173 Protein; hFc Tag

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£181.00

SKU:: PME100542
Additional Names:: ERIS;hMITA;hSTING;MITA;MPYS;NET23;SAVI;STING;STING-beta;TMEM173
Molecular Weight:: The protein has a predicted molecular mass of 53.2 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 90% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: TMEM173
hFc(Glu99-Ala330) TMEM173 (Leu139-Ser379):: hFc(Glu99-Ala330) TMEM173 (Leu139-Ser379)
Extra Details:: This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

Shipping Conditions:: Ambient