Human IL5 Protein; hFc Tag

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£195.00

SKU:: PME100537
Additional Names:: IL-5;TRF;Interleukin-5;EDF
Molecular Weight:: The protein has a predicted molecular mass of 39.3 kDa after removal of the signal peptide.The apparent molecular mass of IL5-hFc is approximately 35-55 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: IL5
IL5(Ile20-Ser134) hFc(Glu99-Ala330):: IL5(Ile20-Ser134) hFc(Glu99-Ala330)
Extra Details:: This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation; maturation; recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor; which is a heterodimer; whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4); interleukin 13 (IL13); and CSF2 . This gene; IL4; and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.

Shipping Conditions:: Ambient