Human TGFB1 Protein; hFc Tag

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£181.00

SKU:: PME100064
Additional Names:: CED;DPD1;IBDIMDE;LAP;TGF-beta1;TGFB;TGFbeta
Molecular Weight:: The protein has a predicted molecular mass of 38.9 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 90% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: TGFB1
hFc(Glu99-Ala330) TGFB1(Ala279-Ser390):: hFc(Glu99-Ala330) TGFB1(Ala279-Ser390)
Extra Details:: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide; and is found in either a latent form composed of a mature peptide homodimer; a LAP homodimer; and a latent TGF-beta binding protein; or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation; differentiation and growth; and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells; and mutations in this gene result in Camurati-Engelmann disease.

Shipping Conditions:: Ambient