Mouse ACVR2B Protein; hFc Tag

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£189.00

SKU:: PME-M100116
Additional Names:: ActRIIB; AI047905; 4930516B21Rik
Molecular Weight:: The protein has a predicted molecular mass of 39.8 kDa after removal of the signal peptide. The apparent molecular mass of mACVR2B-hFc is approximately 55-70 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: ACVR2B
Mouse ACVR2B(Ser19-Thr137) hFc(Glu99-Ala330):: Mouse ACVR2B(Ser19-Thr137) hFc(Glu99-Ala330)
Extra Details:: Enables activin binding activity; growth factor binding activity; and protein kinase activity. Involved in blood vessel remodeling; negative regulation of cold-induced thermogenesis; and vasculature development. Acts upstream of or within several processes; including animal organ development; embryonic morphogenesis; and insulin secretion. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures; including alimentary system; egg cylinder; genitourinary system; nervous system; and sensory organ. Used to study right atrial isomerism and visceral heterotaxy. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (activin A receptor type 2B). [provided by Alliance of Genome Resources; Apr 2022]

Shipping Conditions:: Ambient