Mouse CD45 Protein; His Tag

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£178.00

SKU:: PME-M100081
Additional Names:: Ptprc;B220;L-CA;Ly-5;T200;CD45R;Lyt-4
Molecular Weight:: The protein has a predicted molecular mass of 59.5 kDa after removal of the signal peptide. The apparent molecular mass of mCD45-His is approximately 130-250 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: CD45
Mouse CD45(Gln26-Lys566) 6×His tag:: Mouse CD45(Gln26-Lys566) 6×His tag
Extra Details:: Enables several functions; including heparan sulfate proteoglycan binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes; including lymphocyte differentiation; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes; including lymphocyte differentiation; positive regulation of lymphocyte activation; and regulation of protein phosphorylation. Located in external side of plasma membrane; focal adhesion; and membrane raft. Is expressed in several structures; including 3rd branchial arch; alimentary system; cardiovascular system; hemolymphoid system; and placenta. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency; autosomal recessive; T cell-negative; B cell-positive; Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C). [provided by Alliance of Genome Resources; Apr 2022]

Shipping Conditions:: Ambient