Mouse PD-L1 Protein; hFc Tag

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£169.00

SKU:: PME-M100077
Additional Names:: B7h1;Pdl1;Pdcd1l1;Pdcd1lg1;A530045L16Rik
Molecular Weight:: The protein has a predicted molecular mass of 50.8 kDa after removal of the signal peptide. The apparent molecular mass of mPD-L1-hFc is approximately 55-100 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: PDL1
Mouse PD-L1(Phe19-Arg237) hFc(Glu99-Ala330):: Mouse PD-L1(Phe19-Arg237) hFc(Glu99-Ala330)
Extra Details:: The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells; such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue; this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments; this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq; Sep 2015]

Shipping Conditions:: Ambient