PME-M100070
Mouse NKG2D Protein; hFc Tag
Size
£202.00
- SKU:
- PME-M100070
- Additional Names:
- NK cell receptor D;CD314;Klrk1;Nkg2d
- Molecular Weight:
- The protein has a predicted molecular mass of 42.6 kDa after removal of the signal peptide. The apparent molecular mass of hFc-mNKG2D is approximately 35-55 kDa due to glycosylation.
- Purity:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- NKG2D
- hFc(Glu99-Ala330) Mouse NKG2D(Phe90-Val232):
- hFc(Glu99-Ala330) Mouse NKG2D(Phe90-Val232)
- Extra Details:
- Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells; leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8( ) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx; culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A; RAET1B; RAET1C; RAET1D; RAET1E; H60 and MULT1.[UniProtKB/Swiss-Prot Function]
- Shipping Conditions:
- Ambient