Mouse MMP13 Protein; hFc Tag

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£219.00

SKU:: PME-M100030
Additional Names:: MMP-13;Collagenase 3;Matrix metalloproteinase-13
Molecular Weight:: The protein has a predicted molecular mass of 78.1 kDa after removal of the signal peptide. The apparent molecular mass of mMMP13-hFc is approximately 70-100 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: MMP13
Mouse MMP13(Leu20-Cys472) hFc(Glu99-Ala330):: Mouse MMP13(Leu20-Cys472) hFc(Glu99-Ala330)
Extra Details:: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes; such as embryonic development; reproduction; and tissue remodeling; as well as in disease processes; such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq; Jan 2016]

Shipping Conditions:: Ambient