Human CGRPR-RAMP1 full length protein-MNP

Size

£1,290.00

SKU:: FLP200145
Additional Names:: CALCRL; CRLR; LMPHM8
Molecular Weight:: The human full length CGRPR protein has a MW of 53.0 kDa
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: CGRPR
Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction:: Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction
Extra Details:: The CGRP receptor (CGRPR) is a member of family B G protein coupled receptors (GPCRs); is expressed throughout the trigeminal system; including neurons and endothelial cells. They usually function with accessory proteins such as receptor activity modifying proteins (RAMPs) and Na/H exchange regulatory factors (NHERFs). CGRPR is a heterodimer complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1). Therapeutics for migraine treatment are mostly targeting CRLR-RAMP1 protein-protein interaction surfaces; thereby blocking CGRP activity.