Human TLR5 full length protein-MNP

Size

£1,290.00

SKU:: FLP200143
Additional Names:: MELIOS; SLE1; SLEB1; TIL3
Molecular Weight:: The human full length TLR5 protein has a MW of 97.8 kDa
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from PBS. Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Target:: TLR5
Pathogenic Escherichia coli infection; Toll-like receptor signaling pathway:: Pathogenic Escherichia coli infection; Toll-like receptor signaling pathway
Extra Details:: Toll-like receptor (TLR) family plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin; the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB; which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus; and susceptibility to Legionnaire disease.