FLP100019
Human ADORA2A full length protein-MNP
Size
£1,290.00
- SKU:
- FLP100019
- Additional Names:
- A2aR; ADORA2; RDC8
- Molecular Weight:
- The human full length ADORA2A protein has a MW of 44.7 kDa
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- ADORA2A
- Calcium signaling pathway; Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction:
- Calcium signaling pathway; Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction
- Extra Details:
- A member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily; which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein; an adenosine receptor of A2A subtype; uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions; such as cardiac rhythm and circulation; cerebral and renal blood flow; immune function; pain regulation; and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified; but it is thought to be non-coding.
- Shipping Conditions:
- Ambient