DMC101003
Anti-CCR5 antibody(4F6); IgG1 Chimeric mAb
Size
£198.00
- SKU:
- DMC101003
- Additional Names:
- CC-CKR-5;CCCKR5;CCR-5;CD195;CKR-5;CKR5;CMKBR5;IDDM22
- Application:
- Flow Cytometry
- Purification:
- Purified from cell culture supernatant by affinity chromatography
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Host:
- Rabbit
- Reactivities:
- Human
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Clone:
- 4F6
- Target:
- CCR5
- Extra Details:
- This gene encodes a member of the beta chemokine receptor family; which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages; and is known to be an important co-receptor for macrophage-tropic virus; including HIV; to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2); macrophage inflammatory protein 1 alpha (MIP-1 alpha); macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line; suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq; Jul 2015]
- Shipping Conditions:
- Ambient