1581
Vav 1 oncogene Adenovirus (Ad-VAV1)
Size
£882.00
- SKU:
- 1581
- Additional Names:
- Ad-VAV1|Vav 1 oncogene Adenovirus
- Concentration:
- 1E10 PFU/ml
- Storage Conditions:
- -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Vector Biolabs
- Buffer:
- DMEM, 2% BSA, 2.5% Glycerol
- Species:
- Virus
- Extra Details:
- Guanine nucleotide exchange factors (GEFs) regulate the activity of the small GTP-binding proteins of the Ras superfamily. The Ras family of proteins participate in a diverse array of functions, including signal transduction, cytoskeleton dynamics and intracellular trafficking. Ras proteins cycle between a biologically inactive GDP-bound state and an active GTP-bound state. GEFs catalyze the release of GDP from inactive Ras proteins to enable GTP binding. They include Vav, Vav2, Sos1, Sos2, RCC1, RhoGEF p115, Tiam1, Tiam2, Ral GDS, Ras-GRF1, Ras-GRF2, RasGRP, C3G, FGD1, FGD2, FGD3, NET1, Lbc, Lfc, Lsc, Ost, Frabin, Brx, Dble, Gem and Ect2. Vav has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication., vectorbiolabs
- Shipping Conditions:
- Dry Ice