1520
Cyclin-dependent kinase 5 Adenovirus (Ad-CDK5)
Size
£882.00
- SKU:
- 1520
- Additional Names:
- Ad-CDK5|Cyclin-dependent kinase 5 Adenovirus
- Concentration:
- 1E10 PFU/ml
- Storage Conditions:
- -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Vector Biolabs
- Buffer:
- DMEM, 2% BSA, 2.5% Glycerol
- Species:
- Virus
- Extra Details:
- Cyclin dependent kinases (Cdks) are critical regulators of cell cycle progression that are constitutively expressed throughout the cell cycle. Family members include Cdc2 p34, Cdk2-9, PITSLRE, PCTAIRE-1-3, KKIAMRE, KKIALRE and NKIAMRE. Prototype members of this family include Cdc2 p34 and Cdk2, which function late in the cell cycle, whereas other members, Cdk4, Cdk6 and a related protein Cdc7, are critically involved in the G1 and S phase transitions. Cdks comprise the catalytic subunit of the cell cycle kinases and they associate with specific regulatory subunits to form an active complex. Cyclin H is one such regulatory subunit that preferentially binds to Cdk7 and forms the cyclin H/Cdk7 complex, which then phosphorylates Cdc2, Cdk2 and Cdk4 to regulate cell cycle progression. Cdk5/p25 is reported to be responsible for the mitotic-like phosphoepitopes present in neurofibrillary tangles and Cdk5 has a critical role in neurodegenerative mechanisms., vectorbiolabs
- Shipping Conditions:
- Dry Ice