1351
BRCA1 Adenovirus (Ad-BRCA1)
Size
£631.00
- SKU:
- 1351
- Additional Names:
- Ad-BRCA1|BRCA1 Adenovirus
- Concentration:
- 1E10 PFU/ml
- Storage Conditions:
- -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Vector Biolabs
- Buffer:
- DMEM, 2% BSA, 2.5% Glycerol
- Species:
- Virus
- Extra Details:
- The breast cancer susceptibility gene, BRCA1, which maps to chromosome 17q is expressed in numerous tissues, including breast and ovary. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast and ovarian cancer. Mutations within the BRCA1 gene may account for at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer.This adenovirus expresses the human BRCA1 transcript variant 5 (NM_007299). This variant differs in the 5' UTR, uses two alternate in-frame splice sites in the central coding region, and lacks an alternate exon in the 3' coding region that results in a frameshift, compared to variant 1. So this variant is shorter and has a distinct C-terminus, compared to BRCA1 isoform 1.Please contact us if you need adenoviruses expressing other isoforms of human BRCA1., vectorbiolabs
- Shipping Conditions:
- Dry Ice