1289
PUMA (DBH3) Adenovirus (Ad-PUMA (DBH3))
Size
£631.00
- SKU:
- 1289
- Additional Names:
- Ad-PUMA (DBH3)|PUMA (DBH3) Adenovirus
- Concentration:
- 1E10 PFU/ml
- Storage Conditions:
- -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Vector Biolabs
- Buffer:
- DMEM, 2% BSA, 2.5% Glycerol
- Species:
- Virus
- Extra Details:
- PUMA (p53 up-regulated modulator of apoptosis) is a BH3-only protein. Each of the BH3-only group of proteins contains an amphipathic Bcl-2 homology (BH) domain. These proteins act as sensors of discrete apoptotic stimuli, antagonizing or activating the function of multidomain Bcl-2 family proteins by interacting with them. This in turn triggers a cascade of downstream events, such as the collapse of mitochondrial membrane potential, release of the apoptogenic mitochondrial proteins cytochrome c and SMAC, and activation of caspases.PUMA plays a vital role in mediating the apoptotic responses to p53. It can be activated by p53 directly through p53-responsive elements in its promoter region. The PUMA protein interacts with Bcl-XL and promotes mitochondrial translocation and multimerization of Bax.This adenovirus expresses human PUMA gene with a 15-aa deletion of the BH3 domain.Reference: Yu J., et al., Mol Cell. 2001 Mar;7(3):673-82. PUMA induces the rapid apoptosis of colorectal cancer cells., vectorbiolabs
- Shipping Conditions:
- Dry Ice