Z0550-01A
ZIPK, Control Peptide (ZIPtide, Zip Kinase)
Size
£512.00
- SKU:
- Z0550-01A
- Purity:
- 95+% HPLC, Mass Spec
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Format:
- Supplied as a white to off-white lyophilized powder.
- Extra Details:
- Synthetic substrate peptide (KKLNRTLSFAEP-G) (linear) for ZIPK. Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N-terminal kinase domain and a C-terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREB family. ZIP kinase has high sequence homology to DAP kinase (death-associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. Applications: Analytical Tests: Peptide identity confirmed by MALDI-ToF MS and Amino Acid analysis. Kinase Assay: Substrate for ZIPK, active. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice