T8051-11
TLR11 (Toll Like Receptor 11)
Size
£655.00
- SKU:
- T8051-11
- Application:
- WB
- Purity:
- Purified by Ion Exchange chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Raised against a peptide corresponding to 16 amino acids near the middle of mouse TLR11 (GenBank accession no. NP_991388)
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
- Extra Details:
- Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). TLR11 is one of three mouse TLRs that lack a human ortholog (6). It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system (7). Applications: Can be used for detection of TLR11 by Western blot at 0.5-2ug/ml. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice