PMA, 99+% (Phorbol 12-myristate 13-acetate)

Size

£475.00

SKU:: T5600-03C
Molecular Weight:: 616.83
Purity:: ≥99% (HPLC, TLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 16561-29-8
Format:: Colorless film
Extra Details:: Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin. Synonyms: PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate; Phorbol 12-myristate 13-acetate; tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester CAS No: 16561-29-8 Molecular Formula: C36H56O8 Molecular Weight: 616.83 Appearance: Colorless film Purity: ≥99% (HPLC, TLC) Solubility: DMSO, Methanol, Ethanol Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Light sensitive.