T5585-27

Tissue Inhibitor of Metalloproteinases 2 (TIMP2)

Size

£819.00

SKU:: T5585-27
Purity:: Purified.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Synthetic peptide corresponding to aa178-193, YRGAAPPKQEFLDIED of human TIMP-2.
Clone:: 2Q762 (67-4H11)
Format:: Supplied as a liquid in 0.1M PBS, pH 7.0, 2% BSA (Protease free).
Extra Details:: TIMP-2 is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kD Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kD Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. Applications: Suitable for use in Western Blot, ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (PLP fixed tissue): 5ug/ml Immunohistochemistry (Frozen): 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.