T5585-10W
Timp2 (Tissue Inhibitor of Metalloproteinase 2, timp2a)
Size
£448.00
- SKU:
- T5585-10W
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Goat
- Immunogen:
- Synthetic peptide corresponding to C-TEKIIHGRQSDH, from timp2, at the internal region of the protein (NP_878294.1).
- Format:
- Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
- Extra Details:
- Tissue inhibitors of metalloproteinases (TIMPs) are involved in the control of matrix-metalloproteinase (MMP) activity as a key inhibitor in tissue. Expression of MMPs and TIMPs are controlled during tissue remodeling to maintain a balance in the regulation of extracellular matrix turnover and other morphogenic processes. TIMP-2 has also been reported to have growth factor properties. Zebrafish TIMP-2 shows high similarity to human TIMP-2 with all critical features conserved. Immunoreactive zebrafish TIMP-2 was detected at the protein level with a recombinant antibody for human TIMP-2. TIMP-2 was shown to be expressed as early as the one cell stage, and blockage of TIMP-2 translation resulted in abnormal zebrafish development. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:16,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice