T3700-02
THAP11 (THAP Domain Containing 11, Ronin, CTG-B43a, CTG-B45d, HRIHFB2206)
Size
£825.00
- SKU:
- T3700-02
- Purity:
- Purified by Protein A/G affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant corresponding to Gly226Met314 in THAP11 expressed in E. coli (Q96EK4).
- Clone:
- 11D112
- Format:
- Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
- Extra Details:
- The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. THAP11, also known as Ronin, is a 3644kD member of the Thanatos-associated protein family. It is ubiquitously expressed and through its repression of cMyc transcription, blocks cell proliferation. Human THAP11 is 314aa in length. It contains a DNA binding THAP zinc-finger domain (aa5-81), an NLS (aa98-104 a polyGln region (aa104-146 an Ala-rich segment (aa 197-221 and a C-terminal coiled coil region (aa255-305 THAP11 is phosphorylated on Thr25. Over aa226-314 human and mouse THAP11 are 100% identical in aa sequence. Applications: Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice