T2510-45
Temozolomide
Size
£320.00
- SKU:
- T2510-45
- Molecular Weight:
- 194.2
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 85622-93-1
- Format:
- White to Off-White Solid
- Extra Details:
- Imidazotetrazine alkylating agent. An antineoplastic. A cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer therapy. MGMT (O6-methylguanine DNA methyl transferase) repairs TMZ-damaged DNA lesion by covalently transferring O6-methylation on guanine residues to a cysteine residue on the MGMT, forming the basis of TMZ-resistance in cancer treatment. CAS No: 85622-93-1 Molecular Formula: C₆H₆N₆O₂ Solubility: Dichloromethane, DMSO, Methanol Primary Target: DNA guanine residues Molar Mass: 194.2 Melting Point: >177°C (dec.) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Ambient