S9116-07
Synphilin 1 (Not for Export EU)
Size
£825.00
- SKU:
- S9116-07
- Purity:
- Serum
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to aa829-847 from human synphilin-1.
- Format:
- Supplied as a lyophilized powder. Reconstitute with 50ul sterile ddH2O.
- Extra Details:
- Synphilin 1 is a cytoplasmic protein that is enriched in the neurophils of normal human brain. Although the exact function of synphilin 1 is unknown, it may possibly have a role as a cytoskeletal protein based on the presence of ankyrin-like repeats and an ATP, GTP-binding domain. It has been shown to be novel is its ability to associate in vivo with alpha-synuclein to form cytoplasmic eosinophilic inclusions. Additionally, it has been observed to be present in Lewy bodies of Parkinson disease, which are composed of alpha-synuclein. Because synphilin 1 is not found in protein aggregates of Alzheimer’s disease, it appears to be specific for alpha-synuclein-containing lesions. Synphilin 1 may facilitate the aggregation of alpha-synuclein into Lewy bodies. Applications: Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry: 1:1000-1:2000. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice