Syndecan 2

Size

£787.00

SKU:: S9111-40B
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to the internal region of human syndecan-2 (fibroglycan).
Format:: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Extra Details:: Syndecans are heparan sulfate proteoglycans that consist of a hydrophobic membrane-spanning domain, a short cytoplasmic domain, and an extracellular domain. Syndecans contain a small core protein with distinct functional domains to which multiple glycosaminoglycan chains are linked, predominantly of the heparan sulfate variety. Syndecans are involved in cell adhesion, tissue morphogenesis and differentiation and regulation of cell responsiveness to soluble growth-regulatory compounds. These functions are attributed primarily to the glycan moieties. Syndecans also interact with growth factors such as fibroblast growth factor and epidermal growth factor. Syndecan 2 was originally cloned from embryonic fibroblasts. Syndecan 2 is expressed in epithelial-mesenchymal interfaces, and prechondrogenic and preosteogenic mesenchymal condensations, which are areas of high morphogenetic activity. Syndecan 2 is involved in the mitogenic activity and signaling of Granulocyte-Macrophage Colony-stimulating factor in osteoblasts, and has been shown to have a regulatory role in matrix assembly. Increased Syndecan 2 expression is important for colon carcinoma behavior, and Syndecan 2 regulates tumorgenic activity by regulating adhesion and proliferation in colon carcinoma cells. Applications: Suitable for use in Immunofluorescence/Immunocytochemistry, Western Blot, Immunohistochemistry, and ELISA. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:100-1:500 Immunohistochemistry (Paraffin): 1:10-1:100 Immunofluorescence (IC): 1:100-1500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice