Sunitinib Maleate (Sutent, Sunitinib Malate, SU-11248, PHA-290940AD, PNU-290940AD)

Size

£212.00

SKU:: S8032
Molecular Weight:: 532.56
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 341031-54-7
Extra Details:: A multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK). Sunitinib and its active metabolite (SU012662) are selective inhibitors of multiple receptor tyrosine kinases, including platelet-derived growth factor receptor and vascular endothelial growth factor receptor, that are associated with tumor growth and angiogenesis. Sunitinib dose-dependently inhibited stem cell factor (SCF)-induced phosphotyrosine levels on KIT (IC50 = 1-10nM) and reduced SCF-stimulated ERK1/2 phosphorylation with an IC50 value consistent with that for inhibition of KIT phosphotyrosine levels. Sunitinib also inhibited SCF-stimulated proliferation in NCI-H526 cells (IC50 = 2nM). Synonyms: Sutent; N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; (2S)-hydroxy-butanedioic acid; Sunitinib Malate; SU-11248; PHA-290940AD; PNU-290940AD CAS No: 341031-54-7 Molecular Formula: C₂₆H₃₃FN₄O₇ Molecular Weight: 532.56 Purity: ≥98% Appearance: Yellow to orange powder Method of Determining Identity: Proton NMR Spectroscopic Analysis Storage and Stability: Store at 4ºC. Stable for 6 months after receipt.