S8031-97

Sunitinib, Free Base

Size

£160.00

SKU:: S8031-97
Molecular Weight:: 398.47
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 557795-19-4
Extra Details:: Sunitinib (as the malate salt) is the active ingredient in the drug sold under the trade name Sutent. This drug is a small molecule receptor tyrosine kinase inhibitor that has been approved in at least one country for the treatment of patients having gastrointestinal stromal tumors or renal cell carcinomas. Synonyms: N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; SU-11248; Sutent; PHA-290940AD; PNU-290940AD CAS No: 557795-19-4 Molecular Formula: C22H27FN4O2 Molecular Weight: 398.47 Appearance: Yellow powder Purity: ≥99% (HPLC, TLC) Solubility: Soluble in DMSO at 40mg/ml; soluble in ethanol at 1.4mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Elemental Analysis Calculated: %C: 66.31 %H: 6.83 %F: 4.77 %N: 14.06 Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.