S7965-35C
Staphylococcal Enterotoxin B (SEB)
Size
£288.00
- SKU:
- S7965-35C
- Purity:
- Purified by Protein G affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- SEB purified from Staphylococcus aureus
- Clone:
- 3H276
- Format:
- Supplied as a liquid in PBS, pH 7.2. No preservatives added.
- Extra Details:
- Staphylococcal enterotoxin B (SEB) is an enterotoxin secreted by Staphylococcus aureus. The bacterium thrives on meet, baking and dairy products and also colonizes in host nasal passageway. Ingestion of SEB contaminated food is the common cause of “food poisoning”, manifested by flu-like symptoms, vomiting, diarrhea and intestinal cramps. In severe cases, SEB can cause respiratory failure and systemic toxic shock. These symptoms are the results of increased membrane permeability and abnormal activation of T-lymphocytes by SEB. SEB acts as a superantigen by binding directly to major histocompatibility complex class II (MHCII) on antigen presenting cells, thus, causing massive CD4 and CD8 T-cells activation and cytokine production. If unchecked, the process can result in systemic organ failure and death. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Hybridoma: Sp2/0-AG14 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice