STAM2 (Signal Transducing Adapter Molecule 2, STAM-2, Hrs-binding Protein, HBP)

Size

£642.00

SKU:: S7954-10C
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to C-QSIDPTDSKPDSQD, from human STAM2, at the internal region of the protein (NP_005834.3).
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Extra Details:: STAM2 (signal transducing adapter molecule 2), a ubiquitously expressed protein and member of the STAM family, involved in cytokine-mediated signal transduction, downstream of JAK kinases. STAM2 is involved in mediating the endocytic sorting of ubiquitinated membrane proteins on early endosomes, binding directly with ubiquitin, and co-localizing with Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and Eps15 (epidermal growth factor receptor substrate 15), in clathrin-containing endosomal microdomains. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Western Blot: 1-3ug/ml, observed in human spleen lysates on ~70kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.