SPZ1 (Spermatogenic Leucine Zipper Protein 1, FLJ25709, Testis-specific Protein 1, Testis-specific Protein NYD-TSP1, TSP1)

Size

£537.00

SKU:: S6010-10
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to aa40-90 of human SPZ1.
Format:: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Extra Details:: Spermatogenic leucine zipper protein 1 is a member of the basic helix-loop-helix (bHLH) family of transcription factors which is expressed specifically in the testis and epididymis. Studies show that SPZ1 acts downstream of mitogen-activated protein kinase (MAPK), an extracellular signal-regulated kinase 1:2 to up-regulate cell proliferation and tumorigenesis. Also, through an interaction with proliferating cell nuclear antigen (PCNA) promoter, SPZ1 induced cell proliferation concomitant with an increase in PCNA gene expression. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Testis Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.