S4283
SPG21, 1-308 aa, Recombinant, Human (Spastic paraplegia 21 isoform a, ACP33, BM-019, GL010, Maspardin, MAST, Acid cluster protein 33, ACP33, BM-019, GL010, Maspardin, MASPARDIN, MAST, Spastic paraplegia 21 autosomal recessive Mast syndrome protein)
Size
£512.00
- SKU:
- S4283
- Molecular Weight:
- 37.1
- Purity:
- Purified. ≥95% by SDS-Page
- Storage Conditions:
- -70°C
- Supplier:
- United States Biological
- Format:
- Supplied as a liquid in Tris-HCL, pH 8.0.
- Extra Details:
- Spastic paraplegia 21(SPG21), also known as Maspardin, binds to the hydrophobic C-terminal amino acids of CD4 and may play a role as a negative regulatory factor in CD4-depenent T-cell activation. This protein is widely expressed in various tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in SPG21 cause Mast syndrome, an autosomal-recessive complicated form of hereditary spastic paraplegia characterized by dementia, thin corpus callosum and white matter abnormalities. Recombinant human SPG21 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. Molecular Weight: 37.1kD (328aa) Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGEIKVSPDY NWFRGTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP PVSGTADVFF RQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE YTHKSPRVHS LILCNSFSDT SIFNQTWTAN SFWLMPAFML KKIVLGNFSS GPVDPMMADA IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDVFDQSAL STEAKEEMYK LYPNARRAHL KTGGNFPYLC RSAEVNLYVQ IHLLQFHGTK YAAIDPSMVS AEELEVQKGS LGISQEEQ Endotoxin Level: ≤ 1.0 EU per 1 ug of protein (determined by LAL method) Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.
- Shipping Conditions:
- Blue Ice