S1040-03B

SOCS 3 (Suppressor of Cytokine Signaling 3, SOCS3, SOCS-3, ATOD4, Cytokine-inducible SH2 Protein 3, CIS3, CIS-3, Cish3, STAT-induced STAT Inhibitor 3, SSI3, SSI-3)

Size

£704.00

SKU:: S1040-03B
Application:: WB
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Full-length human SOCS3 protein.
Clone:: SO1
Format:: Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
Extra Details:: SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: reducing conditions. Optimal dilutions to be determined by the researcher. Positive Control: HeLa human cervix carcinoma cell line Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.