S1013-86W
Siomycin A (Mutabilycin, Sporangiomycin, Antibiotic 6741-21, Mutabillicin)
Size
£526.00
- SKU:
- S1013-86W
- Molecular Weight:
- 1648.9
- Purity:
- > 95% by HPLC
- Storage Conditions:
- 4°C
- Supplier:
- United States Biological
- CAS Number:
- 12656-09-6
- Format:
- Supplied as a white solid.
- Extra Details:
- Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity discovered in 1969. Recently, siomycin was discovered to be a potent inhibitor of the oncogenic transcription factor-forkhead box M1, FoxM1 (previously known as HFH-11B, Trident, WIN or MPP2). The reduced transcription activity was reflected in the down regulation of protein and mRNA levels of FoxM1 and effects on down stream genes – Cdc25B, Survivin and CENPB. In vitro, siomycin was demonstrated to inhibit FoxM1 induced cell growth on soft agar and selectively kill transformed but not normal cells.
- Shipping Conditions:
- Blue Ice