S1013-21D

SHIP, ID (INPP5D, SH2-containing Inositol 5-phosphatase 1, SH2 Domain-containing Inositol Phosphatase 1, SHIP-1, Inositol Polyphosphate-5-phosphatase of 145kD, SIP-145, p150Ship Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, hp51CN, SHIP1)

Size

£696.00

SKU:: S1013-21D
Purity:: Purified by ammonium sulfate precipitation.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide selected from the Center region of human INPP5D (KLH).
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and it is a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.