Sentrin 1 (Sentrin, GAP Modifying Protein 1, GMP1, PIC1, PIC-1, Small Ubiquitin-related Modifier 1, SUMO1, SMT3, SMT3 Homolog 3, SMT3 Suppressor of Mif Two 3 Homolog 1, SMT3C, SMT3H3, Ubiquitin Homology Domain Protein PIC1, Ubiquitin-like 1, Ubiquitin-like Protein SMT3C, Ubiquitin-like Protein UBL1, UBL1) (Not for Export EU)

Size

£735.00

SKU:: S0750-01G1
Purity:: Serum
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: A synthetic peptide (AKPST EDLGDKKEGE Y) as part of human SUMO-1 peptide (aa: 6-21) conjugated to diphtheria toxoid. This antigen shares 100% identity with SUMO-1 of rat.
Format:: Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.
Extra Details:: Ubiquitin-like protein which binds to a wide range of target proteins. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. SUBUNIT: Covalently attached to a number of proteins such as PML, RANGAP1, HIPK2, SP100, p53, p73alpha, MDM2, JUN and DNMT3B. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, PIAS1, EXOSC9, TDG, RAD51 and RAD52. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Cellular Localization: Nucleus; nuclear membrane. Nucleus; nucleoplasm; nuclear speckle. Cytoplasm. Belongs to the ubiquitin family. SMT3 subfamily. Contains 1 ubiquitin-like domain. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice