R3005-01
Rottlerin
Size
£288.00
- SKU:
- R3005-01
- Molecular Weight:
- 516.54
- Purity:
- ≥95%
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 82-08-6
- Format:
- Orange-brown powder
- Extra Details:
- Rottlerin is an inhibitor of PRAK (IC50 1.9M), MAPKAP Kinase 2 (IC50 5.4M) and CaM Kinase III (3-6M). Rottlerin inhibits PMA-induced edema in mouse ear. For use as an Inhibitor of PRAK, MAPKAP kinase 2, and CaM Kinase III activity. Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Synonyms: (E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one;_x000B_3’-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2’,4’,6’-trihydroxy-5’-methyl-acetophenone; (2E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one; Mallotoxin; NSC 56346; NSC 94525 CAS No: 82-08-6 Molecular Formula: C30H28O8 Molecular Weight: 516.54 Appearance: Orange-brown powder. Purity: ≥95% Melting Point: 200-205°C(lit.) Solubility: Soluble in DMSO, chloroform or 100% ethanol. Not soluble in water. Warning! Toxic. Wear gloves/mask when handling product. Avoid contact by all modes of exposure. Storage and Stability: Powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO, chloroform, or 100% ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice