R2031-73Z3

RIP (Receptor Interacting Protein, Cell Death Protein RIP, FLJ39204, Receptor-interacting Protein 1, RIP1, RIP-1, Receptor-interacting Serine/threonine Protein Kinase 1, Receptor-interacting Serine/threonine-protein Kinase 1, Receptor (TNFRSF)-interacting Serine/threonine Kinase 1, RIPK1, Serine/threonine Protein Kinase RIP)

Size

£531.00

SKU:: R2031-73Z3
Application:: WB
Purity:: Purified by Protein G affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to aa350-400 of human RIP1.
Format:: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Extra Details:: RIP1 belongs to the Ser/Thr protein kinase family and promotes apoptosis and activation of NF-kappaB. It associates with the intracellular domain of TNFRSF6. Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. It plays a critical role in tumor necrosis factor-alpha (TNF-alpha)-induced I kappaB kinase (IKK) activation. It is also an essential component of the TLR3-Trif−mediated NF-B signaling pathway. RIP1 is one of the critical components involved in mediating DNA damage-induced, p53-independent cell death. It is expressed in tissues of intestine, small intestine, brain and testis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Ramos cell lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.