Rebeccamycin

Size

£435.00

SKU:: R1281-15
Molecular Weight:: 570.4
Purity:: >99% by HPLC
Storage Conditions:: +4°C
Supplier:: United States Biological
CAS Number:: 93908-02-2
Extra Details:: Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. It displays a selective antitumour activity against several cell lines. Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II. Analogues of rebecamycin are currently in several clinical trials for cancer therapy. Purity: >99% by HPLC Solubility: Soluble in THF or DMSO. Poorly soluble in methanol and water. Related to: Staurosporine, Antibiotic UCN-01, Antibiotic UCN-02