Nuclear Receptor ROR-gamma (Nuclear Receptor RZR-gamma, Nuclear Receptor Subfamily 1 Group F Member 3, Retinoid-related Orphan Receptor-gamma, RORC, NR1F3, RORG, RZRG)

Size

£594.00

SKU:: R1183-30M
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to aa1-50 of human RORg.
Format:: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Extra Details:: ROR-gamma is a 560aa novel DNA-binding transcription factor belonging to the ROR:RZR orphan nuclear receptor subfamily. The specific functions of this protein are not known. However, reports suggest that this protein is a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR-gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR-gamma shares 50-51% sequence identity with RORA and RORB and is 88% identical to mouse ROR-gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Jurkat, NIH 3T3 or RAW cell lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice