R0470

Radicicol (Monorden)

Size

£332.00

SKU:: R0470
Molecular Weight:: 364.78
Purity:: > 99% by HPLC
Storage Conditions:: 4°C/-20°C
Supplier:: United States Biological
CAS Number:: 12772-57-5
Format:: White solid
Extra Details:: Radicicol is a resorcylic acid lactone produced by several fungal species that exhibits broad spectrum antifungal and antitumor activity. Radicicol has been the subject of extensive investigation and been shown to inhibit protein tyrosine kinase, induce the differentiation of HL-60 cells into macrophages, block cell cycle at G1 and G2, suppress NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos and also suppress the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of plasminogen activator production by vascular endothelial cells. Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility