P9109-40L10

PTPRM (Receptor-type Tyrosine-protein Phosphatase mu, Protein-tyrosine Phosphatase mu, R-PTP-mu, PTPRL1)

Size

£642.00

SKU:: P9109-40L10
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide corresponding to C-KLIRQVDKWQEEYN from an internal region of human PTPRM. Species sequence homology: canine and mouse.
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Extra Details:: PTP mu, a R2A receptor is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. The Human PTP mu gene is localized on chromosome 18pter-q11, a region with frequent abnormalities implicated in Human cancer. PTP mu may be important in responses to pathological conditions associated with the loss of cell-cell interactions in the heart. Applications: Suitable for use in Peptide ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Peptide ELISA: 1:16,000 Immunohistochemistry (paraffin): 3.75ug/ml Heat induced antigen retrieval in citrate buffer, pH 6.0 is required. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice