P9107-56-ML550
PP6C (protein phosphatase 6, catalytic subunit, FLJ92648, MGC12249, PP6C, PPP6, Serine/threonine-protein phosphatase 6 catalytic subunit) (MaxLight 550)
Size
£978.00
- SKU:
- P9107-56-ML550
- Purity:
- Purified
- Storage Conditions:
- 4°C Do Not Freeze
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to the C-terminus of PP6C.
- Format:
- Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™550.
- Extra Details:
- MaxLight™550 is a new Yellow-Green photostable dye conjugate comparable to Alexa Fluor™546, 555, DyLight™549 , Cy3™, TRITC and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (550nm); Emission (575nm); Extinction Coefficient 150,000. PP6 (PPP6, Protein Phosphatase 6) is a Ser/Thr protein phosphatase that is part of the type 2 PPP family that includes PP2A, PP4, and PP6. All of these phosphatases are sensitive to low doses of Okadaic acid. PP6 is conserved among eukaryotes and the function of PP6 is relatively unknown, but the Saccharomyces cerevisiae homolog of Sit4 has been implicated in the cell regulation of G1 to S progression (Stefansson, 2006). Knockdown of PP6 in mammals has been related to a very high rate of apoptosis. Based on this and other information, PP6 is believed to function in cell cycle regulation. PP6C encodes the catalytic subunit of the protein phosphatase. PP6C binds to PP6R1, PP6R2, and PP6R3 through the SAPS domain of PP6R (Stefansson, 2006). This complex is known to bind to and protect IKBE from degradation in response to TNF alpha treatment (Stefansson, 2006). Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: Jurkat Cell Lysate Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.
- Shipping Conditions:
- Blue Ice