P9107-11H
Protein Phosphatase 1 Regulatory Subunit 1A (PPP1R1A, I1, I-1, IPP1, IPP-1, Protein Phosphatase Inhibitor 1)
Size
£537.00
- SKU:
- P9107-11H
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to aa50-100 of human IPP-1.
- Format:
- Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
- Extra Details:
- IPP-1 is a type 1 serine/threonine specific protein phosphatase inhibitor belonging to the protein phosphatase inhibitor 1 family. IPP-1 has multiple domains that target cellular PP1 complexes and establishes it as a cellular regulator of eIF2alpha phosphorylation. IPP-1 becomes active only after phosphorylation of a threonine residue by cAMP-dependent protein kinase. It is a selective inhibitor of protein phosphatase-1 (PP1) and regulates several PP1-dependent signaling pathways, including cardiac contractility and regulation of learning and memory. It is a widely expressed regulatory protein known to play an important role in hormonal control of glycogen metabolism. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human ovary lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice