P9053-50

Prostaglandin Transporter, Rat, Control Peptide (PGT)

Size

£416.00

SKU:: P9053-50
Purity:: Highly purified
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
Extra Details:: A 20aa Peptide sequence near the C-terminus of rat PGT Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic anions from the blood by a process called "renal secretion". Besides kidney, anionic substrates are also transported in other organs, e.g., choroid plexus, eye, airway, and placenta. Several multispecific OATs (OAT1-3, OAT-K1 and OATK2) and OATPs (organic anion transporting polypeptides; oatp1-3, LST-1, and PGT), have been cloned and characterized from various tissues. OATPs family of proteins share significant sequence homology, and general secondary protein structure (up to 12 transmembrane domains with cytoplasmic N and C-terminus). Prostaglandins and thromboxanes play important physiological, pathological, and therapeutical roles in health and disease. PGT (prostaglandin transporter also known as martin F/G), a member of oatp family, mediates transport of PGs (PGD2, PGE1, PGE2, PGF2a) from the circulation. PGT (rat/human 643 aa; 12 TM) is expressed in brain, stomach, ileum, jejunum, and kidney but not in heart or skeletal muscle. Applications: ELISA: 1:10-50K for neat serum and 0.5-1ug/ml for affinity pure.